Human Sera
Cayman Chemical LaHydroxyglutarIc AcIdod 50mg
A 5/6 desaturase inhibitor reduces liver arachidonate content by 50 in mice at 3 mg/kg increases mead acid content and inhibits leukotriene C4 synthesis in murine mastocytoma cells at 5 UM
Cayman Chemical LHomopropargyl GlycInhydr 50mg
A major metabolite of DHA that is produced via oxidation by cytochrome P450 epoxygenases suppresses aggregation and thromboxane synthesis in isolated platelets
Cayman Chemical SaracatInIb 50mg
A potent nhbtor of nuclear transport blocks the nteracton of CRM1 wth NES preventng the export of a broad range of protens nhbts export of mRNA from the nucleus by blockng the nuclear export of mRNAbndng protens blocks the nuclear export of p53 and prevents entry of human normal fbroblasts nto the S phase of the cell cycle thus nhbtng prolferaton orgnally dentfed as an antfungal agent
Cayman Chemical 6aMethylprednIsoLN 21hemI 50mg
An inhibitor of SPHK2 (Ki 9 8 UM) inhibits SPHK2 (IC50 60 M) without affecting SPHK1 activity up to 100 M but does reduce SPHK1a protein levels in cells via an SPHK1-indirect proteasomal-dependent mechanism at 5-25 UM inactive against a panel of 20 lipid-regulated kinases at 50 M inhibits proliferation of a variety of human cancer cell lines (IC50s 6 12 2 32 8 and 48 1 UM respectively) reduces tumor growth in a mouse syngeneic model of mammary adenocarcinoma at 35 and 100 mg/kg every other day reduces colonic inflammation in mouse and rat models of Crohn s disease
Cayman Chemical Neurodazine 50mg
A cannabdol (CBD) analog that acts as a selectve antagonst of abnormal CBD (AbnCBD) at the nonCB1/CB2 endothelal receptor does not bnd to CB1 or CB2 receptors at concentratons up to 30 UM and nhbts the vasorelaxant effects of AbnCBD n vtro and n whole anmals blocks the AbnCBDnduced actvaton of the Ptdns 3knase/Akt pathway n human umblcal ven endothelal cells
Cayman Chemical ProtodIoscIn 50mg
A selectve nhbtor of COX-2 (C50s 0 005 and 140 UM for human recombnant COX-2 and COX-1 respectvely) decreases LPS-nduced producton of PGE2 n solated human whole blood (C50 0 89 UM) reduces carrageenan-nduced paw edema and adjuvant-nduced arthrts n rats (ED50s 10 2 and 0 032 mg/kg respectvely)
Cayman Chemical CarboplatIn 100mg
A fully saturated anandamde analog does not bnd to the murne CB1 receptor does not compete wth AEA as a substrate for FAAH
Cayman Chemical TrIgonlaDIoscIn 50mg
azdo-FTY720 s a hghly photoreactve analog of FTY720 that can be used to dentfy receptor bndng stes for ths lgand 14080
Cayman Chemical olna ntdysntca Consn 50mg
An affinity probe which allows 8-iso PGA2 to be detected through an interaction with the biotin ligand
Cayman Chemical cIstrIsmethoxy RSvRatrol 100mg
An analytical reference standard categorized as a synthetic cannabinoid has been found in illicit substances seized by law enforcement reduces tactile allodynia in rats and mice intended for research and forensic applications
Cayman Chemical SunItInIbmalate 50mg
An nternal standard for the quantfcaton of 1314-dhydro-15-keto PGD2 by GC- or LC-MS
Cayman Chemical Olmesartn MedoxomIl 100mg
Plant Armoracia rusticana Assay KitsKit Co Olmesartn MedoxomIl 100mg
Cayman Chemical ImatInIbmesylate 100mg
A small molecule activator of stem cell renewal that allows the propagation of OG2 mES cells for at least 10 passages in an undifferentiated state activity is mediated by the combined inhibition of RasGAP and ERK1 with Kd values of 98 and 212 nM respectively