Human Sera
Cayman Chemical Gncclovr 50mg
An active metabolite of valganciclovir and an antiviral nucleoside derivative; reduces human, monkey, mouse, and guinea pig CMV replication in plaque reduction assays (EC50s = 1.3-70 µM); topical application decreases disease severity and corneal leukocyte infiltration in a cat model of ocular FHV-1 epithelial infection at 0.15%; prevents allograft histologic injury and NK and myeloid cell infiltration in a mouse model of murine CMV infection with renal transplantation at 15 mg/kg; induces tumor regression in a K-BALB murine sarcoma model using a mixed population of HSV TK positive or negative cells
Innovative Research Inc Sngl Dnr Hmn Crohn Disease Srm
Single Donor Human Crohn's Disease Serum - Single Donor Human Crohn's Disease Serum from Innovative Research is whole blood derived. Available volumes are variable, and range from 0.5ml to 1.0ml per vial (you can select your exact samples from our inventory, if desired). A detailed patient history and clinical information is recorded at the time of draw, and multiple samples and plasma/serum matched sets from the same donor are often available. Innovative Research has a wide network of collection centers, which allows us to collect from nearly any donor type. We are able to deliver to you a list of available samples that includes comprehensive donor data so that you can select the particular samples that best fit with your research requirements.
Cayman Chemical D2PMhydrochlorIde 50mg
A psychoactive designer drug; also used in organic synthesis to prepare the Corey-Bakshi-Shibata catalyst; intended for forensic purposes
Bioworld GemCell U.S. Origin Human Serum AB, 100 mL
GemCell™ human serum AB is collected from healthy male donors of the AB serotype at FDA-licensed facilities in the United States. This material is defibrinated from Source Plasma AB. All donor units are tested for viral markers (HIVAg, HBsAg, HIV 1 and 2) and found to be nonreactive.Specifications0.1µm sterile-filteredShips on dry ice.
Cayman Chemical Lamotrgn 50mg
An anticonvulsant; inhibits Nav1.2, Nav1.5, and Nav1.8 in HEK293 cells expressing the recombinant human channels (IC50s = 10, 62, and 96 μM, respectively); inhibits high voltage-activated calcium currents in isolated rat cortical neurons (IC50 = 12.3 µM), an effect that can be reversed by ω-conotoxin GVIA and ω-agatoxin IVA; protects against MES-induced seizures in mice and rats (ED50s = 10.1 and 7.4 µmol/kg, respectively); decreases mechanical allodynia in a rat model of neuropathic pain induced by spinal nerve ligation (ED50 = 47 µmol/kg)
Cayman Chemical ResorcInolnaphthaleIn 50mg
Increases the activity of angiotensin-converting enzyme 2 (ACE2) in vitro (EC50 = 19.5 μM)
Cayman Chemical Fludarabn 50mg
An intermediate active metabolite of fludarabine phosphate; inhibits the proliferation of RPMI-8226, MM.1S, and MM.1R multiple myeloma cells (IC50s = 1.54, 13.48, and 33.79 µM, respectively); increases Bax levels and decreases Bid, XIAP, and survivin levels, in RPMI-8226 cells at 2 UG/ml; an inhibitor of SARS-CoV-2 RdRp (EC50 = 1.06 µM); completely inhibits DNA synthesis in an SA-NH murine sarcoma model at 200 mg/kg; reduces tumor growth in an RPMI-8226 mouse xenograft model at 40 mg/kg; reduces tumor growth in an L1210 murine leukemia model
Cayman Chemical KevetrInhydrochlorIde 50mg
An activator of p53; increases levels of activated p53 and expression of p21 in A549 cells and decreases expression of the transcription factor E2F1 in a variety of cell lines; decreases cell viability in a panel of cancer cell lines (mean IC50 = 0.49 μM); reduces tumor growth in various mouse xenograft models at 200 mg/kg
Cayman Chemical UmbelIferon 100mg
A derivative and metabolite of coumarin with diverse biological activities; inhibits growth of human ACHN renal, A549 lung, HCT15 colon, and LNCaP prostate carcinoma as well as Dakiki myeloma and HL-60 lymphoma cells at 250-300 UG/ml; increases ROS production and halts the cell cycle in KB human oral carcinoma cells; has antidepressant-like activity in a rat model of depression induced by chronic unpredictable mild stress at 15 and 30 mg/kg; used as a ratiometric pH indicator with ex/em = 330 and 370/460 nm at low and high pH, respectively
Cayman Chemical ClofentezIn 50mg
An acaricide; has broad-spectrum activity against various plant-feeding mite species; lethal to wild-type, but not chs1 mutant, T. urticae mite eggs (LC50s = 1.2 and >5,000 mg/L, respectively); induces formation of thyroid tumors in male rats from 13-1,000 mg/kg per day
Cayman Chemical 4MethyLMbelIferylaDGluc 50mg
A fluorogenic substrate for α-glucosidase; is cleaved by α-glucosidase to release the fluorescent moiety 4-MU; ex = 320 and 360 nm at low (1.97-6.72) and high pH (7.12-10.3), respectively; em = 445 to 455 nm, increasing as pH decreases; has been used to quantify α-glucosidase activity in infant blood spot samples in the diagnosis of Fabry and Pompe diseases
Cayman Chemical ACtyl TetrapeptID3ACTAt 100mg
A biomimetic peptide; reases protein levels of type III collagen and total laminins in MRC5 human fibroblasts at 1 μM; reverses corticoid-induced decreases in collagen VII expression at the dermal-epidermal junction in human skin explants
Cayman Chemical CItrulInated Hsp70R155 Po 1ea
Immunogen: Peptide from the internal region of human Hsp70 containing a citrulline at residue 155 • Host: Rabbit • Cross Reactivity: (+) Citrullinated Hsp70, Citrullinated GRP78; (-) Hsp70, other citrullinated Hsp proteins • Species Reactivity: (+) Human; other species not tested • Applications: ELISA and WB
Cayman Chemical GenIposIdIc AcId 100mg
An iridoid glycoside with diverse biological activities; inhibits TPA-induced EAr edema in mice by 91.01% when administered topically at 0.1 mg/ear; increases survival rate, attenuates increases in ALT activity and TNF-α levels in serum, as well as hepatic levels of MDA, and prevents decreases in hepatic GSH levels in a mouse model of fulminant hepatic failure induced by D-galactosamine and LPS at 50 mg/kg; decreases systolic blood pressure and heart rate and increases plasma levels of ANP in spontaneously hypertensive rats at 100 mg/kg
Cayman Chemical SwertIamarIn 50mg
A secoiridoid glycoside with diverse biological activities; scavenges ABTS radicals and hydrogen peroxide (IC50s = 2.83 and 5.7 μM, respectively); inhibits NO production in IL-1β-stimulated FLSs isolated from rat hindpaw at 50 μg/ml; inhibits oleate-induced lipid droplet and triglyceride accumulation in HepG2 cells at 25 μg/ml; decreases liver lipid accumulation, ballooning degeneration, and TNF-α and IL-6 levels in a mouse model of fructose-induced NAFLD at 50 mg/kg per day; decreases fasting blood glucose and serum cholesterol levels in rat model of STZ-induced diabetes at 50 mg/kg per day