Human Sera
Cayman Chemical AzoxystrobIn 50mg
A broad-spectrum fungicide (LC95s = 20 = 2.9 µM); disrupts mRNA expression of antioxidant-, stress response-, and innate immune-related genes and induces the production of ROS in zebrafish larva at 0.1-100 UG/L; inhibits proliferation of KYSE-150 human esophageal squamous cell carcinoma cells (IC50 = 2.42 UG/ml after 48 hours); reduces tumor growth at 40 mg/kg per day
Cayman Chemical ErgoloIdmesylates 50mg
A mixture of alkaloids with diverse biological activities; blocks norepinephrine-induced reflex vasodilation and vasoconstriction in dogs when injected into the kidney at a dose of 0.15 mg; blocks norepinephrine-induced cAMP production in rat brain cortical homogenates ex vivo in a dose-dependent manner; acts as an erectogenic agent in rats
Cayman Chemical RaltItrexed 50mg
An inhibitor of thymidylate synthase (Ki = 62 nM); inhibits the growth of L1210 mouse lymphocytic leukemia cells in vitro (IC50 = 8 nM); reduces thymidylate synthase activity and completely eliminates tumors in a mouse L1210:ICR ascitic tumor model at 4 mg/kg; reduces tumor growth and the number of metastases in an HCT116-luc mouse xenograft model
Cayman Chemical IsoquercetIn 100mg
A flavonoid with diverse biological activities; reduces viral titers of H5N1 influenza isolates by 79.66% in a plaque assay at 1 ng/ml; inhibits apoptosis, increases cell viability, and decreases the level of ROS in an oxygen-glucose deprivation/reoxygenation assay in primary rat hippocampal neurons at 25, 50, and 100 UG/ml; decreases TNF-α-induced cell death in primary mouse hepatocytes (IC50 = 37.5 µM); reduces infarct volume and neurological symptoms in a rat model of MCAO at 50 mg/kg
Cayman Chemical 3 3 DIpropylthIdIcarbocnI 50mg
A fluorescent dye; has been used to monitor cell membrane potential; ex/em = 622/670 or 622/688 nm when cells are depolarized or hyperpolarized, respectively; fluorescence intensity decreases in hyperpolarized cells and increases in depolarized cells; induces membrane hyperpolarization, increases in intracellular sodium, and decreases in intracellular potassium in Ehrlich ascites tumor cells at 3 µM; increases potassium membrane permeability by 64.6% in Ehrlich ascites tumor cells in the presence of ouabain; reduces cellular ATP levels in the absence of glucose and induces acid production and inhibits oxygen consumption in the presence of glucose in Ehrlich ascites tumor cells at 3 µM
Cayman Chemical BenocyclIdIn 50mg
A derivative of phencyclidine that acts as a potent and selective dopamine reuptake inhibitor (IC50 = 8 nM); intended for forensic and research applications
Cayman Chemical DMnose6PhosphATsodIum 100mg
A phosphorylated aldohexose that can be used to produce glucose, mannitol, or N-glycans; also a ligand for both cation-dependent and -independent receptors and binds, as part of an N-glycan, to MRH domains on other proteins
Cayman Chemical TalnIflumate 50mg
A prodrug form of niflumic acid; decreases the rate of chloride/bicarbonate exchange in isolated mouse intestinal villous epithelial cells at 100 µM; dietary administration increases survival but has no effect on the number of crypt goblet cells in the jejunum or cecum in a cystic fibrosis mouse model of distal intestinal obstructive syndrome at 88 mg/kg
Cayman Chemical RamoplnIn Complex 250mg
An antibiotic complex; active against clinical isolates of S. aureus, S. pyogenes, S. pneumoniae, and S. faecalis (MICs = 0.016-2 UG/ml) but not Gram-negative bacteria or C. albicans (MICs = ≥128 UG/ml); inhibits cell wall synthesis in B. subtilis at 0.5 UG/ml; effective against systemic S. pyogenes, S. pneumoniae, and S. aureus infections in mice (ED50s = 0.081, 0.14, and ~25 mg/kg per day, respectively)
Cayman Chemical OleIc nhydrIde 50mg
A fatty acid anhydride; inhibits sphingosine-induced phosphorylation of p32 in Jurkat T cells from 30-100 μM; has been used in the synthesis of various phospholipids and triglycerides
Cayman Chemical PerfluoroctnsulfonamIde 100mg
A perfluoroalkyl substance; induces hepatic macrophage and neutrophil accumulation and fibrosis in zebrafish larvae when administered in tank water from 0.1-100 UG/L; has been found in municipal wastewater networks
Cayman Chemical PRfluorohexnsulfonIc ACD 100mg
A perfluoroalkyl substance; activates PPARα in a reporter assay using COS-1 cells expressing the human or mouse receptor from 5-100 µM; has been found in landfill leachate and sea and river water
Cayman Chemical 7-KetosItosterol 50mg
A phytosterol and phytosterol oxidation product; a thermal oxidation product of sitosterol; inhibits the proliferation of HL-60 cells (IC50 = 45.6 µM)
Cayman Chemical MecamylamInhydrochlorIde 50mg
A noncompetitive nicotinic acetylcholine receptor antagonist with preferential activity at the α3β4 subtype (IC50 = 90-640 nM) compared to α4β2, α3β2, and α7 subtypes (IC50s range from 1-7 μM)
Cayman Chemical 3Deoxy3fluorothymIdIn 50mg
A nucleoside analog; a TK1 substrate; inhibits TK1 and TK2 (Kis = 6 and 10 µM, respectively); inhibits HIV-1 reverse transcriptase (EC50 = 5 nM) and the replication of HIV-1 in MT-4 cells (EC50 = 5 nM); decreases mtDNA levels and the OCR and induces upregulation of CD11b in OCI-AML-2 and MV4-11 cells; reduces tumor growth in an OCI-AML-2 AML mouse xenograft model at 50 mg/kg; a radiolabeled form is commonly used as a PET tracer for in vivo imaging of tumors